No label defined (Q33268)

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  • Impact of hormonal therapy on HIV-1 immune markers in cis women and gender minorities.
Language Label Description Also known as
English
No label defined
No description defined
  • Impact of hormonal therapy on HIV-1 immune markers in cis women and gender minorities.

Statements

Impact of hormonal therapy on HIV-1 immune markers in cis women and gender minorities. (English)
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Although sex hormones are recognized to induce immune variations, the effect of hormonal therapy use on immunity is only poorly understood. (English)
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Here, we quantified how hormonal therapy use affects HIV-1 immune markers in cis women (CW) and trans women and non-binary people (TNBP) with HIV. (English)
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We considered CD4, CD8 and lymphocyte measurements from cis men (CM), CW and TNBP in the Swiss HIV Cohort Study. (English)
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We modelled HIV-1 markers using linear mixed-effects models with an interaction between 'gender' (CW, TNBP) and 'hormonal therapy use' (yes/no). (English)
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Models were adjusted on age, ethnicity, education level, time since start of antiretroviral therapy and use of intravenous drugs. (English)
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We assessed the inflammatory effect of hormonal therapy use in 31 TNBP using serum proteomics measurements of 92 inflammation markers. (English)
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We included 54 083 measurements from 3092 CW and 83 TNBP, and 147 230 measurements from 8611 CM. (English)
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Hormonal therapy use increased CD4 count and CD4:CD8 ratio in TNBP more than in CW (p<sub>interaction</sub> = 0.02 and 0.007, respectively). (English)
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TNBP with hormonal therapy use had significantly higher CD4 counts [median = 772 cells/μL, interquartile range (IQR): 520-1006] than without (617 cells/μL, 426-892). (English)
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This was similar to the effect of CW versus CM on CD4 T cells. (English)
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Hormonal therapy use did not affect serum protein concentrations in TNBP. (English)
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This study highlights the potential role of hormonal therapy use in modulating the immune system among other biological and social factors, especially in TNBP with HIV. (English)
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October 2024
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October 2024
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Swiss HIV Cohort Study (English)
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A (English)
Anagnostopoulos (English)
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G (English)
Dollenmaier (English)
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D (English)
Jackson-Perry (English)
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L (English)
Salazar-Vizcaya (English)
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25
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10
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1112-1124
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1112
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1124
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