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- Analysis of single nucleotide polymorphisms of the metabotropic glutamate receptors in a transgender population.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
No description defined |
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Statements
Gender incongruence (GI) is characterized by a marked incongruence between an individual's experienced/expressed gender and the assigned sex at birth. (English)
INTRODUCTION (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
It includes strong displeasure about his or her sexual anatomy and secondary sex characteristics. (English)
INTRODUCTION (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
In some people, this condition produces a strong distress with anxiety and depression named gender dysphoria (GD). (English)
INTRODUCTION (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
This condition appears to be associated with genetic, epigenetics, hormonal as well as social factors. (English)
INTRODUCTION (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
Given that L-glutamate is the major excitatory neurotransmitter in the central nervous system, also associated with male sexual behavior as well as depression, we aimed to determine whether metabotropic glutamate receptors are involved in GD. (English)
INTRODUCTION (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
We analyzed 74 single nucleotide polymorphisms located at the metabotropic glutamate receptors (mGluR1, mGluR3, mGluR4, mGluR5, mGluR7 and mGluR8) in 94 transgender <i>versus</i> 94 cisgender people. (English)
METHODS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
The allele and genotype frequencies were analyzed by c2 test contrasting male and female cisgender and transgender populations. (English)
METHODS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
The strength of the associations was measured by binary logistic regression, estimating the odds ratio (OR) for each genotype. (English)
METHODS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
Measurement of linkage disequilibrium, and subsequent measurement of haplotype frequencies were also performed considering three levels of significance: P ≤ 0.05, P ≤ 0.005 and P ≤ 0.0005. (English)
METHODS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
Furthermore, false positives were controlled with the Bonferroni correction (P ≤ 0.05/74 = 0.00067). (English)
METHODS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
After analysis of allele and genotypic frequencies, we found twenty-five polymorphisms with significant differences at level P ≤ 0.05, five at P ≤ 0.005 and two at P ≤ 0.0005. (English)
RESULTS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
Furthermore, the only two polymorphisms (rs9838094 and rs1818033) that passed the Bonferroni correction were both related to the metabotropic glutamate receptor 7 (mGluR7) and showed significant differences for multiple patterns of inheritance. (English)
RESULTS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
Moreover, the haplotype T/G [OR=0.34 (0.19-0.62); P<0.0004] had a lower representation in the transgender population than in the cisgender population, with no evidence of sex cross-interaction. (English)
RESULTS (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
We provide genetic evidence that the mGluR7, and therefore glutamatergic neurotransmission, may be involved in GI and GD. (English)
CONCLUSION (English)
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Copyright © 2024 Fernández, Ramírez, Lorente-Bermúdez, Gómez-Gil, Mora, Guillamon and Pásaro. (English)
2024
Rosa (English)
Fernández (English)
R
Karla (English)
Ramírez (English)
K
Roberto (English)
Lorente-Bermúdez (English)
R
Esther (English)
Gómez-Gil (English)
E
Mireia (English)
Mora (English)
M
Antonio (English)
Guillamon (English)
A
Eduardo (English)
Pásaro (English)
E
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (English)