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- Determinants of Bone Mass Accrual in Transgender and Gender Diverse Youth Undergoing Pubertal Suppression Therapy.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
No description defined |
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Statements
Gender-affirming care for gender diverse and transgender (GDTG) youth includes puberty suppression with gonadotropin-releasing hormone agonists (GnRHa). (English)
INTRODUCTION/BACKGROUND (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Puberty is a critical period of bone mass accrual, and pubertal suppression may impact bone health. (English)
INTRODUCTION/BACKGROUND (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Previous studies have shown a decrease in areal bone mineral density (aBMD) Z-score while on puberty suppression. (English)
INTRODUCTION/BACKGROUND (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
However, the rate of bone mass accrual and its determinants during GnRHa therapy are not known. (English)
INTRODUCTION/BACKGROUND (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
This is a retrospective chart review of GDTG youth with aBMD assessment within six months of starting GnRHa monotherapy at Cincinnati Children's Hospital Medical Center between 01/2011 and 12/2022. (English)
METHODOLOGY (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
In individuals with follow-up aBMD assessment, we calculated their aBMD velocity and generated Z-scores using reference data from the Bone Mineral Density in Childhood Study. (English)
METHODOLOGY (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
The determinants of baseline height-adjusted aBMD and aBMD velocity Z-scores were assessed with multiple linear regression models. (English)
METHODOLOGY (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Thirty-six participants (36% assigned female at birth (AFAB), mean age at first aBMD assessment 12 ± 1.1 years) had baseline height-adjusted aBMD Z-score of -0.053 ± 0.79. (English)
RESULTS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Among 16 participants with follow-up aBMD assessment, the mean aBMD velocity Z-score was -0.42 ± 1.13 (-0.27 ± 0.79 in AFAB vs -0.52 ± 1.32 in assigned male at birth, p = 0.965). (English)
RESULTS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Baseline aBMD Z-scores significantly correlated with age at the first aBMD assessment (adjusted R<sup>2</sup> 0.124, p = 0.02) with combined modeling including age at first aBMD assessment and BMI Z-score being most significant (adjusted R<sup>2</sup> 0.21, p = 0.008). (English)
RESULTS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Only BMI Z-scores were positively associated with the aBMD-velocity Z-scores (adjusted R<sup>2</sup> 0.255, p = 0.046). (English)
RESULTS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
GDTG youth undergoing GnRHa therapy appeared to have below-average aBMD velocity Z-scores. (English)
CONCLUSIONS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
A lower BMI Z-score was a determinant of lower baseline height-adjusted aBMD and aBMD velocity Z-scores. (English)
CONCLUSIONS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Building on previous studies, our study highlights aBMD velocity as a novel technique for bone health surveillance in GDTG youth. (English)
CONCLUSIONS (English)
Copyright © 2024 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. (English)
2024
Samantha (English)
Roberge (English)
S
Taylor (English)
Roberge (English)
T
Nat (English)
Nasomyont (English)
N
Declaration of competing interest The authors declare there is no conflict of interests. (English)