No label defined (Q31644)
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- Histological ovarian features and hormonal determinations in assigned females at birth transgender individuals according to different testosterone preparations.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
No description defined |
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Statements
Distinct androgen formulations have been used as gender-affirming hormone treatment, but little is known about the specific changes that may occur in the ovary depending on the testosterone preparation used. (English)
INTRODUCTION (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
The study aims to evaluate the histological modifications of the ovarian tissue and the hormonal changes after gender-affirming surgery based on the testosterone preparation employed, such as testosterone cypionate or undecanoate. (English)
INTRODUCTION (English)
no value
Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
Unicenter transversal cohort study. (English)
DESIGN (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
Sixty transmasculine persons before and after gender-affirming surgery. (English)
MATERIALS AND METHODS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
A histological examination of the ovaries was conducted, including the follicular population and the characterization of the ovarian stroma. (English)
MATERIALS AND METHODS (English)
no value
Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
Hormonal status (testosterone, estradiol, FSH, and LH) were also assessed before and after the procedure. (English)
MATERIALS AND METHODS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
The median age of participants was similar between the two groups (27.9 vs. 26.7 years, p = 0.27). (English)
RESULTS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
There were no differences in all hormonal determinations before gender-affirming surgery between the groups. (English)
RESULTS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
After surgery, FSH levels increased significantly, especially in the testosterone undecanoate group compared to the cypionate group (72.3 vs. 38.3 U/L, p = 0.02), consistent with LH determinations (43.0 vs. 23.4 U/L, p = 0.02). (English)
RESULTS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
However, no regimen modification was required for any individual. (English)
RESULTS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
No statistical differences were observed in any parameter concerning the follicular population, nor were there any variances in the thickness of the tunica albuginea (p = 0.85) or the proportion of luteinized stromal cells. (English)
RESULTS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
Nevertheless, there was a tendency toward increased luteinization in the testosterone cypionate group (88.2% vs. 76.9%, p > 0.05). (English)
RESULTS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
In a cohort of transmasculine individuals using different androgen preparations, histological analysis of ovarian tissue revealed comparable findings. (English)
CONCLUSIONS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
Both groups exhibited similar follicular populations and comparable modifications in stromal tissue. (English)
CONCLUSIONS (English)
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Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
However, significant differences were observed in hormonal profiles, although no modification in testosterone dosage was needed. (English)
CONCLUSIONS (English)
no value
Copyright © 2024 Borrás, Barral, Fabregues, Casals, Mora, Orois, Méndez, Saco, Goday and Manau. (English)
2024
Yasmina (English)
Barral (English)
Y
Francesc (English)
Fabregues (English)
F
Mireia (English)
Mora (English)
M
Aida (English)
Orois (English)
A
Marta (English)
Méndez (English)
M
Adela (English)
Saco (English)
A
Anna (English)
Goday (English)
A
12 November 2024
12 November 2024
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (English)