No label defined (Q31620)
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- Clinical and Biochemical Outcomes in Transgender Individuals Undergoing Hormone Therapy: Protocol for a Systematic Review.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
No description defined |
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Statements
Monitoring of various clinical outcomes and parameters, such as lipid levels, is recommended in transgender individuals undergoing hormone therapies. (English)
BACKGROUND (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
However, comprehensive data to inform these recommendations is scarce. (English)
BACKGROUND (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
This study aims to conduct a systematic review and meta-analysis to synthesize evidence from existing literature on the effect of exogenous hormone therapy on clinical and biochemical outcomes for transgender adolescents and adults. (English)
OBJECTIVE (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
We will search multiple electronic databases and will include prospective and retrospective observational studies with and without a control group. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
The study population will include transgender individuals undergoing hormone therapy with testosterone or estrogen. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
Comparisons will include age-matched, cisgender individuals and changes from baseline. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
Primary outcomes include changes in or the development of abnormal lipid parameters. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
Secondary outcomes include BMI, weight, height, and blood pressure for age, serum testosterone or estrogen levels, and development of disease including hypertension, diabetes, fatty liver disease, obesity, adverse cardiac events, as well as all-cause mortality. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
The meta-analysis will pool the studies where applicable, and meta-regressions will be conducted to evaluate effect modifiers. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
The GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach will be used to evaluate the overall certainty of evidence. (English)
METHODS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
We will summarize the selection of the eligible studies using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart. (English)
RESULTS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
The results will be presented in a table summarizing the evidence. (English)
RESULTS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
Data collection is ongoing, and the paper is expected to be published in Spring 2025. (English)
RESULTS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
This systematic review will summarize and evaluate the evidence of the clinical and biochemical outcomes associated with hormone therapies for transgender individuals. (English)
CONCLUSIONS (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
PROSPERO CRD42024483138; https://tinyurl.com/yc4sfvnb. (English)
TRIAL REGISTRATION (English)
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
PRR1-10.2196/57931. (English)
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) (English)
no value
©Emily Sattora, Karen Teelin, Christopher Prendergast, Abigail Smith, James Evans, Aamer Imdad. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 12.11.2024. (English)
2024
Emily (English)
Sattora (English)
E
Karen (English)
Teelin (English)
K
Christopher (English)
Prendergast (English)
C
Abigail (English)
Smith (English)
A
James (English)
Evans (English)
J
12 November 2024
12 November 2024