No label defined (Q31496)
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- Observational study of effects of HIV acquisition and antiretroviral treatment on biomarkers of systemic immune activation.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
No description defined |
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Statements
To assess whether biomarkers of systemic inflammation are associated with HIV acquisition or with the timing of ART initiation ("immediate", at diagnosis, versus "deferred", at 24 weeks post-diagnosis) in men-who-have-sex-with-men (MSM) and transgender women, we conducted a retrospective study comparing inflammatory biomarkers in participants' specimens collected before infection and after [...] (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
We measured biomarkers in four longitudinally collected plasma, including two specimens collected from each participant before and two after HIV acquisition and confirmed ART-suppression. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Biomarkers were quantified by enzyme-linked immuno-assay or Meso Scale Discovery. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
When evaluating systematic variation in these markers over time, we found that multiple biomarkers consistently varied across participants' two pre-infection or two post-ART-suppression specimens. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Additionally, we compared changes in biomarkers after vs before HIV acquisition. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Across 47 participants, the levels of C-reactive protein (CRP), monocyte chemo-attractant protein-1, tumor necrosis factor-α and interferon gamma-induced protein-10 significantly increased while leptin and lipopolysaccharide binding protein (LBP) significantly decreased following HIV infection. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Randomization to deferred-ART initiation was associated with greater increases in CRP and no decrease in LBP. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Acquisition of HIV appeared to induce systemic inflammation, with elevation of biomarkers previously associated with infections and cardiovascular disease. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Initiation of ART during the early weeks of infection tempered the increase in pro-inflammatory biomarkers compared to delaying ART for ~24 weeks after HIV diagnosis. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
These findings provide insight into potential mediators by which immediate-ART initiation improves health outcomes, perhaps because immediate-ART limits the size of the HIV reservoir or limits immune dysregulation that in turn trigger systemic inflammation. (English)
Copyright: © 2024 Kosmider et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (English)
2024
Ewelina (English)
Kosmider (English)
E
Jackson (English)
Wallner (English)
J
Ana (English)
Gervassi (English)
A
Rachel A (English)
Bender Ignacio (English)
RA
Delia (English)
Pinto-Santini (English)
D
German (English)
Gornalusse (English)
G
Urvashi (English)
Pandey (English)
U
Paul T (English)
Edlefsen (English)
PT
Javier R (English)
Lama (English)
JR
Ann C (English)
Duerr (English)
AC
Lisa M (English)
Frenkel (English)
LM
31 August 2024
8 July 2024
The authors have declared that no competing interests exist. (English)