Transgender patients and gender-affirming hormone therapy through the mid-life (Q29890)
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- Transgender patients and gender-affirming hormone therapy through the mid-life.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Transgender patients and gender-affirming hormone therapy through the mid-life |
No description defined |
|
Statements
The menopause transition and post-menopause period marks a time of dynamic physiological and hormonal change. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Cisgender women commonly experience vasomotor symptoms, genitourinary symptoms, and changes in bone health. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
The transgender population, including those assigned female at birth (AFAB) and those assigned male at birth (AMAB), has been understudied in terms of experiences through the menopause transition and midlife. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Additionally, there is no formal recommendation or guidance on continuation of gender-affirming hormone therapy (GAHT) through midlife. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
While gender-affirming therapies for transgender patients are well defined and supported by organizational guidelines, including from the World Professional Association for TGD Health (WPATH) (Standards of Care 8, SOC8) and from the Endocrine Society (2017), evidence on continuation of therapy and dose adjustments into mid-life are lacking. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Data from a few large cohort studies and small cross-sectional studies suggest increased risk of venous thromboembolism (VTE), stroke and myocardial infarction in those AMAB on GAHT. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
For those AFAB on testosterone therapy, risks of cardiovascular disease and stroke and to bone health are not well defined, given inconsistent findings from large cohort studies. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Currently, the decision to continue GAHT for transgender patients is guided by patient preference along with clinician guidance. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Further research is warranted regarding risks of continuing GAHT into mid-life for both AMAB and AFAB patients. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Given the significant benefit of GAHT in this population, however, this data would be most helpful for counseling on risks along with appropriate monitoring and prevention for related morbidities during mid-life in the setting of GAHT use. (English)
Copyright © 2024 Elsevier B.V. All rights reserved. (English)
2024
Jaya M (English)
Mehta (English)
JM
Sarah (English)
Kanell (English)
S
Charlie E A (English)
Borowicz (English)
CEA
Molly Ainsman (English)
Fisher (English)
MA
27 September 2024
27 September 2024
Declaration of competing interest The authors declare that they have no competing interest. (English)