Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors: A retrospective cohort study (Q29775)

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  • Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors: A retrospective cohort study.
  • Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors
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English
Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors: A retrospective cohort study
No description defined
  • Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors: A retrospective cohort study.
  • Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors

Statements

title
Venous thromboembolism in transgender and gender non-binary youth is rare and occurs in the setting of secondary risk factors: A retrospective cohort study. (English)
1 reference
stated in
PubMed
abstract
The risk of venous thromboembolism (VTE) with gender-affirming hormone therapy (GAHT) in transgender and gender non-binary (TNB) youth is unclear. (English)
source label
BACKGROUND (English)
subsection NLM category
background section
series ordinal
1
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
To identify the rate of VTE in a cohort of TNB youth followed in the transgender health clinic at Boston Children's Hospital, and to investigate the impact of congenital thrombophilia diagnosis on the use of GAHT. (English)
source label
OBJECTIVE (English)
subsection NLM category
objective section
series ordinal
2
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
ICD-9 and ICD-10 codes were used to identify eligible individuals, defined as (i) having a diagnosis of gender dysphoria and (ii) venous thromboembolism (VTE). (English)
source label
METHODS (English)
subsection NLM category
methods section
series ordinal
3
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
Data were abstracted from a review of medical records. (English)
source label
METHODS (English)
subsection NLM category
methods section
series ordinal
4
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
A second data query assessed TNB individuals who had an associated thrombophilia diagnosis. (English)
source label
METHODS (English)
subsection NLM category
methods section
series ordinal
5
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
The primary analysis included 1860 individuals. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
6
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
Total 942 individuals (50.6%) had started GAHT at the time of data analysis. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
7
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
Mean age (±SD) at GAHT initiation was 16.8 (±1.9) years. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
8
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
Five thrombotic events were identified in three (0.13%) individuals, all in the setting of additional VTE risk factors. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
9
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
Only two of five thrombotic events occurred while receiving GAHT. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
10
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
The rate of VTE in the GAHT cohort did not statistically differ from the rate of VTE in the non-GAHT cohort (0.1% vs. 0.2%, p = .62). (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
11
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
Of the 10 individuals diagnosed with a congenital thrombophilia, two transmasculine individuals received prophylactic anticoagulation prior to GAHT. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
12
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
No VTE has been reported to date in this cohort. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
13
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
In our cohort, VTE was rare in the TNB youth and was not associated with GAHT use. (English)
source label
CONCLUSIONS (English)
subsection NLM category
conclusion section
series ordinal
14
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
TNB youth with congenital thrombophilia have not developed VTE in the setting of GAHT use to date. (English)
source label
CONCLUSIONS (English)
subsection NLM category
conclusion section
series ordinal
15
copyright statement
© 2024 Wiley Periodicals LLC. (English)
date copyrighted
2024
rights holder
Wiley Periodicals
1 reference
stated in
PubMed
date published
November 2024
1 reference
stated in
PubMed
date issued
November 2024
1 reference
stated in
PubMed
volume
71
1 reference
stated in
PubMed
issue
11
1 reference
stated in
PubMed
page(s)
e31284
1 reference
stated in
PubMed
page start
e31284
1 reference
stated in
PubMed
 
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