Endometrial cancer and endometrial changes in transgender men: Insights from Japanese individuals on testosterone (Q28545)
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- Endometrial cancer and endometrial changes in transgender men: Insights from Japanese individuals on testosterone.
- Endometrial cancer and endometrial changes in transgender men
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Endometrial cancer and endometrial changes in transgender men: Insights from Japanese individuals on testosterone |
No description defined |
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Statements
Endometrial changes in Japanese transgender men (TGM) on testosterone use remain elucidated. (English)
AIM (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
This study aims to present TGM with endometrial cancer and insights from a literature review of similar cases. (English)
AIM (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Furthermore, we investigated the correlation between endometrial cancer and severe obesity in TGM who underwent gender-affirming surgery. (English)
AIM (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Between July 2020 and April 2023, two groups were assessed: 2 TGM with endometrial cancer and 43 TGM without cancer who underwent gender-affirming surgery. (English)
METHODS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
A literature review for TGM with endometrial cancer was conducted. (English)
METHODS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Clinical data were retrospectively collected, and histopathological evaluation of female genital organs was performed. (English)
METHODS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Two TGM with endometrial cancer and an additional four similar cases were identified through a literature search. (English)
RESULTS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
These TGM had severe obesity (body mass index [BMI] ≥30 kg/m<sup>2</sup>) and long-term testosterone use, indicating a possible link between endometrial cancer and these factors. (English)
RESULTS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Subsequently, we investigated the 43 TGM without cancer. (English)
RESULTS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
We revealed 30% with obesity (BMI ≥25), only three cases of severe obesity (BMI ≥30), and a significant correlation between testosterone use duration and BMI in TGM without cancer. (English)
RESULTS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Histological examination revealed focal proliferative endometrium in 51% of cases and polycystic ovarian changes in 77%. (English)
RESULTS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Our observations suggest a potential link between severe obesity, prolonged testosterone use, and endometrial cancer in transgender men. (English)
CONCLUSIONS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Histological changes in the female genital tract highlighted frequent focal proliferative endometrium, even under testosterone therapy. (English)
CONCLUSIONS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Further research should focus on larger, multi-institutional studies to confirm these findings and establish endometrial cancer screening for Japanese TGM. (English)
CONCLUSIONS (English)
© 2024 Japan Society of Obstetrics and Gynecology. (English)
2024
Mariko (English)
Nakahara (English)
M
Hiroshi (English)
Yoshida (English)
H
Aiko (English)
Sakamoto (English)
A
Takeshi (English)
Taguchi (English)
T
Masaya (English)
Uno (English)
M
Tomoyasu (English)
Kato (English)
T
Mitsuya (English)
Ishikawa (English)
M
3 November 2024
3 November 2024