The natural course of bone mineral density in transgender youth before medical treatment; a cross sectional study (Q28183)
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- The natural course of bone mineral density in transgender youth before medical treatment; a cross sectional study.
- The natural course of bone mineral density in transgender youth before medical treatment
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | The natural course of bone mineral density in transgender youth before medical treatment; a cross sectional study |
No description defined |
|
Statements
Bone mineral density (BMD) Z-scores decrease during puberty suppression in transgender youth. (English)
OBJECTIVE (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
Assessment of treatment impact has been based on the assumption that without intervention, BMD Z-scores remain stable. (English)
OBJECTIVE (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
However, the natural course of BMD in this population is unknown. (English)
OBJECTIVE (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
Retrospective cross-sectional study. (English)
DESIGN (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
Dual-energy X-ray absorptiometry scans prior to medical intervention were included from 333 individuals assigned male at birth (AMAB) and 556 individuals assigned female at birth (AFAB) aged 12-25 years. (English)
METHODS (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
The relationship between age and BMD Z-scores of sex assigned at birth was analysed for the lumbar spine (LS), total hip (TH), femoral neck (FN), and total-body-less-head (TBLH), adjusted for height SDS, height-adjusted lean mass Z-score, and whole body percentage fat Z-score. (English)
METHODS (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
In individuals AMAB, the BMD Z-score was negatively associated with age between 12 and 22 years: LS -0.13/year (95% confidence interval, CI -0.17; -0.10); TH -0.05/year (95% CI -0.08; -0.02); FN -0.06/year (95% CI -0.10; -0.03); and TBLH -0.12/year (95% CI -0.15; -0.09). (English)
RESULTS (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
Adjusting for height-adjusted lean mass Z-score attenuated the association at the LS and TBLH and eliminated the association at the TH and FN. (English)
RESULTS (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
BMD Z-scores and age were not associated between 22 and 25 years. (English)
RESULTS (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
In individuals AFAB, BMD Z-scores were only associated with age at the TBLH (-0.08/year, 95% CI -0.12; -0.04) between age 12 and 20 years. (English)
RESULTS (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
In individuals AMAB aged 12-22 years prior to any treatment, BMD Z-scores were inversely correlated with age. (English)
CONCLUSION (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
This could imply that BMD increases less in individuals AMAB than in the general population, and that changes in Z-score during puberty suppression and subsequent hormone supplementation are not necessarily due to treatment, but possibly related to lifestyle factors. (English)
CONCLUSION (English)
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
2024
Maria Anna Theodora Catharina (English)
van der Loos (English)
MATC
Lidewij Sophia (English)
Boogers (English)
LS
Daniel Tatting (English)
Klink (English)
DT
Martin (English)
den Heijer (English)
M
Chantal Maria (English)
Wiepjes (English)
CM
Sabine Elisabeth (English)
Hannema (English)
SE
11 October 2024
11 October 2024