Bone health in transgender assigned female at birth people: effects of gender-affirming hormone therapy and gonadectomy (Q27579)
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- Bone health in transgender assigned female at birth people: effects of gender-affirming hormone therapy and gonadectomy.
- Bone health in transgender assigned female at birth people
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Bone health in transgender assigned female at birth people: effects of gender-affirming hormone therapy and gonadectomy |
No description defined |
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Statements
Gender-affirming hormone therapy (GAHT) and gender-affirming surgery (GAS) may be desired by transgender and gender-diverse (TGD) individuals who want to affirm their gender identity. (English)
INTRODUCTION (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Testosterone is the basis of GAHT for transgender individuals assigned female at birth (AFAB), whereas GAS can involve hysterectomy, bilateral salpingectomy, bilateral oophorectomy (BO), thorax masculinization, and phalloplasty. (English)
INTRODUCTION (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Our study aimed to evaluate the effects of GAHT on the bone health of TGD AFAB individuals who have undergone or not undergone BO. (English)
INTRODUCTION (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
This was a single-center, longitudinal study with retrospectively collected data. (English)
METHODS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
TGD AFAB GAHT-naïve individuals were enrolled and underwent dual-energy X-ray absorptiometry scans and laboratory tests (hormonal and bone metabolism parameters) at baseline and after 5 and 10 years of GAHT. (English)
METHODS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Two hundred and forty-three TGD AFAB people were included in this study. (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Seventy-five subjects had completed data for 5 years and 19 subjects for 10 years of GAHT. (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
At baseline, low bone density (Z-score < -2.0) was found in 2.5% (6/243) of subjects for lumbar spine (LS), whereas total hip (TH) and femoral neck (FN) Z-scores and laboratory tests were within the normal female range. (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
After stratifying by physical activity, the physically active group showed significantly higher LS BMD and Z-scores (p ≤ 0.05). (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Five years after the start of GAHT, a significant reduction in LS (p ≤ 0.05), TH (p ≤ 0.001), and FN (p ≤ 0.01) Z-scores was detected. (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
A significant reduction in the Z-scores of all three bone sites was observed only in the subgroup that had undergone BO. (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
After 5 years of GAHT, estradiol levels were significantly decreased compared to those in baseline (p ≤ 0.001). (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Significantly higher estradiol levels were detected in the 5-year no-BO subgroup compared to those in the 5-year BO subgroup (p ≤ 0.001). (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
A significant reduction in LS and TH Z-scores were observed after 10 years of GAHT. (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
At this time, estradiol levels were significantly decreased compared to those in baseline (p ≤ 0.01). (English)
RESULTS (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Bone density in TGD AFAB individuals is comparable to that in their peers prior to GAHT and BO, but those subjects who underwent BO had a reduced Z-score at LS, FN, and TH after 5 years and at LS after 10 years of GAHT. (English)
CONCLUSION (English)
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Copyright © 2024 Sanna, Lami, Giacomelli, Alvisi, Paccapelo, Seracchioli and Meriggiola. (English)
2024
Alessandra (English)
Lami (English)
A
Stefania (English)
Alvisi (English)
S
Alexandro (English)
Paccapelo (English)
A
Renato (English)
Seracchioli (English)
R
Maria Cristina (English)
Meriggiola (English)
MC
12 October 2024
11 October 2024
19 December 2024
0 references
4 February 2025
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14 February 2025
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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (English)