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(Q28183)

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Statements

title
The natural course of bone mineral density in transgender youth before medical treatment; a cross sectional study. (English)
1 reference
stated in
PubMed
abstract
Bone mineral density (BMD) Z-scores decrease during puberty suppression in transgender youth. (English)
source label
OBJECTIVE (English)
subsection NLM category
objective section
series ordinal
1
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
Assessment of treatment impact has been based on the assumption that without intervention, BMD Z-scores remain stable. (English)
source label
OBJECTIVE (English)
subsection NLM category
objective section
series ordinal
2
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
However, the natural course of BMD in this population is unknown. (English)
source label
OBJECTIVE (English)
subsection NLM category
objective section
series ordinal
3
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
Dual-energy X-ray absorptiometry scans prior to medical intervention were included from 333 individuals assigned male at birth (AMAB) and 556 individuals assigned female at birth (AFAB) aged 12-25 years. (English)
source label
METHODS (English)
subsection NLM category
methods section
series ordinal
5
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
The relationship between age and BMD Z-scores of sex assigned at birth was analysed for the lumbar spine (LS), total hip (TH), femoral neck (FN), and total-body-less-head (TBLH), adjusted for height SDS, height-adjusted lean mass Z-score, and whole body percentage fat Z-score. (English)
source label
METHODS (English)
subsection NLM category
methods section
series ordinal
6
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
In individuals AMAB, the BMD Z-score was negatively associated with age between 12 and 22 years: LS -0.13/year (95% confidence interval, CI -0.17; -0.10); TH -0.05/year (95% CI -0.08; -0.02); FN -0.06/year (95% CI -0.10; -0.03); and TBLH -0.12/year (95% CI -0.15; -0.09). (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
7
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
Adjusting for height-adjusted lean mass Z-score attenuated the association at the LS and TBLH and eliminated the association at the TH and FN. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
8
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
BMD Z-scores and age were not associated between 22 and 25 years. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
9
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
In individuals AFAB, BMD Z-scores were only associated with age at the TBLH (-0.08/year, 95% CI -0.12; -0.04) between age 12 and 20 years. (English)
source label
RESULTS (English)
subsection NLM category
results section
series ordinal
10
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
In individuals AMAB aged 12-22 years prior to any treatment, BMD Z-scores were inversely correlated with age. (English)
source label
CONCLUSION (English)
subsection NLM category
conclusion section
series ordinal
11
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
This could imply that BMD increases less in individuals AMAB than in the general population, and that changes in Z-score during puberty suppression and subsequent hormone supplementation are not necessarily due to treatment, but possibly related to lifestyle factors. (English)
source label
CONCLUSION (English)
subsection NLM category
conclusion section
series ordinal
12
copyright statement
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. (English)
publisher
Oxford University Press
on behalf of
European Society of Endocrinology
date copyrighted
2024
rights holder
Maria Anna Theodora Catharina van der Loos
Lidewij Sophia Boogers
Daniel Tatting Klink
Martin den Heijer
Chantal Maria Wiepjes
Sabine Elisabeth Hannema
1 reference
stated in
PubMed
date published
30 September 2024
1 reference
stated in
PubMed
date issued
30 September 2024
1 reference
stated in
PubMed
author
volume
191
1 reference
stated in
PubMed
issue
4
1 reference
stated in
PubMed
page(s)
426-432
1 reference
stated in
PubMed
page start
426
1 reference
stated in
PubMed
page end
432
1 reference
stated in
PubMed
date of article
unknown value
1 reference
stated in
PubMed
conflict-of-interest statement
Conflict of interest: None declared. (English)
series ordinal
1
1 reference
stated in
PubMed
 
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