No label defined (Q31980)
Jump to navigation
Jump to search
No description defined
- Effect of testosterone therapy on breast tissue composition and mammographic breast density in trans masculine individuals.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | No label defined |
No description defined |
|
Statements
The effect of gender-affirming testosterone therapy (TT) on breast cancer risk is unclear. (English)
BACKGROUND (English)
© 2024. The Author(s). (English)
2024
This study investigated the association between TT and breast tissue composition and breast tissue density in trans masculine individuals (TMIs). (English)
BACKGROUND (English)
© 2024. The Author(s). (English)
2024
Of the 444 TMIs who underwent chest-contouring surgeries between 2013 and 2019, breast tissue composition was assessed in 425 TMIs by the pathologists (categories of lobular atrophy and stromal composition) and using our automated deep-learning algorithm (% epithelium, % fibrous stroma, and % fat). (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
Forty-two out of 444 TMIs had mammography prior to surgery and their breast tissue density was read by a radiologist. (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
Mammography digital files, available for 25/42 TMIs, were analyzed using the LIBRA software to obtain percent density, absolute dense area, and absolute non-dense area. (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
Linear regression was used to describe the associations between duration of TT use and breast tissue composition or breast tissue density measures, while adjusting for potential confounders. (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
Analyses stratified by body mass index were also conducted. (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
Longer duration of TT use was associated with increasing degrees of lobular atrophy (p < 0.001) but not fibrous content (p = 0.82). (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
Every 6 months of TT was associated with decreasing amounts of epithelium (exp(β) = 0.97, 95% CI 0.95,0.98, adj p = 0.005) and fibrous stroma (exp(β) = 0.99, 95% CI 0.98,1.00, adj p = 0.05), but not fat (exp(β) = 1.01, 95%CI 0.98,1.05, adj p = 0.39). (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
The effect of TT on breast epithelium was attenuated in overweight/obese TMIs (exp(β) = 0.98, 95% CI 0.95,1.01, adj p = 0.14). (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
When comparing TT users versus non-users, TT users had 28% less epithelium (exp(β) = 0.72, 95% CI 0.58,0.90, adj p = 0.003). (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
There was no association between TT and radiologist's breast density assessment (p = 0.58) or LIBRA measurements (p > 0.05). (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
TT decreases breast epithelium, but this effect is attenuated in overweight/obese TMIs. (English)
CONCLUSIONS (English)
© 2024. The Author(s). (English)
2024
TT has the potential to affect the breast cancer risk of TMIs. (English)
CONCLUSIONS (English)
© 2024. The Author(s). (English)
2024
Further studies are warranted to elucidate the effect of TT on breast density and breast cancer risk. (English)
CONCLUSIONS (English)
© 2024. The Author(s). (English)
2024
Yujing J (English)
Heng (English)
YJ
Gabrielle M (English)
Baker (English)
GM
Valerie J (English)
Fein-Zachary (English)
VJ
Yaileen D (English)
Guzman-Arocho (English)
YD
Vanessa C (English)
Bret-Mounet (English)
VC
Erica S (English)
Massicott (English)
ES
Vanda F (English)
Torous (English)
VF
Stuart J (English)
Schnitt (English)
SJ
Sy (English)
Gitin (English)
S
Paul (English)
Russo (English)
P
Adam M (English)
Tobias (English)
AM
Richard A (English)
Bartlett (English)
RA
Gopal (English)
Varma (English)
G
Despina (English)
Kontos (English)
D
Lusine (English)
Yaghjyan (English)
L
Michael S (English)
Irwig (English)
MS
Jennifer E (English)
Potter (English)
JE
Gerburg M (English)
Wulf (English)
GM
Dr Despina Kontos is an editor of Breast Cancer Research journal. (English)
All other authors declare no competing interests. (English)