The association of depression with all-cause and cardiovascular disease mortality risk among transgender and gender diverse and cisgender patients (Q29591)
Jump to navigation
Jump to search
No description defined
- The association of depression with all-cause and cardiovascular disease mortality risk among transgender and gender diverse and cisgender patients.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | The association of depression with all-cause and cardiovascular disease mortality risk among transgender and gender diverse and cisgender patients |
No description defined |
|
Statements
Transgender and gender diverse (TGD) individuals have elevated mental and physical health disparities and a greater mortality risk compared to their cisgender (non-TGD) counterparts. (English)
BACKGROUND (English)
Published by Elsevier B.V. (English)
We assessed differences in the association of depression with all-cause and cardiovascular disease (CVD) mortality among TGD and cisgender Veterans Administration patients. (English)
METHODS (English)
Published by Elsevier B.V. (English)
A sample of 8981 TGD patients, matched 1:3 with cisgender patients (n = 26,924) patients, was created from administrative and electronic health record data from October 1, 1999 to December 31, 2016. (English)
METHODS (English)
Published by Elsevier B.V. (English)
Cox proportional regression models stratified by gender modality (i.e., TGD and cisgender) were used to assess the hazard of all-cause and CVD mortality associated with a history of depression. (English)
METHODS (English)
Published by Elsevier B.V. (English)
Adjusted models demonstrated that depression was significantly associated with a greater hazard of all-cause mortality among both TGD (aHR:1.18, 95 % CI: 1.04-1.34) and cisgender (aHR:1.22, 95 % CI: 1.17-1.28) patients. (English)
RESULTS (English)
Published by Elsevier B.V. (English)
Similar to all-cause mortality, depression was significantly associated with a greater hazard of CVD mortality among cisgender patients ≥65 years (aHR = 1.23, 95 % CI = 1.13-1.35). (English)
RESULTS (English)
Published by Elsevier B.V. (English)
Findings for TGD patients showed a similar pattern, though results were not significant. (English)
RESULTS (English)
Published by Elsevier B.V. (English)
Hazards may be underestimated since depression may be underdiagnosed. (English)
LIMITATIONS (English)
Published by Elsevier B.V. (English)
Further, we were unable to adjust for other health-related risk factors tied to mortality (e.g., smoking). (English)
LIMITATIONS (English)
Published by Elsevier B.V. (English)
Overall, depression was associated with a greater hazard of all-cause mortality among both TGD and cisgender patients. (English)
CONCLUSION (English)
Published by Elsevier B.V. (English)
Future work should assess the equity of reach, quality, and outcomes of treatment for depression for TGD populations given the lack of attention to addressing the needs of this important patient demographic. (English)
CONCLUSION (English)
Published by Elsevier B.V. (English)
Hill L (English)
Wolfe (English)
HL
Taylor L (English)
Boyer (English)
TL
Emmett R (English)
Henderson (English)
ER
Carl G (English)
Streed (English)
CG
John R (English)
Blosnich (English)
JR
13 September 2024
13 September 2024