(Q31848)
Statements
Persistent infection with high-risk human papillomavirus (HPV) is the causal agent of several cancers including cervical, anal and oropharyngeal cancer. (English)
INTRODUCTION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Transgender men and transmasculine non-binary (TMNB) people with a cervix are much less likely to undergo cervical cancer screening than cisgender women. (English)
INTRODUCTION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Transgender women and transfeminine non-binary (TWNB) people assigned male at birth may be at increased risk of HPV. (English)
INTRODUCTION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Both TMNB and TWNB people face many barriers to HPV testing including medical mistrust due to stigma and discrimination. (English)
INTRODUCTION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
The Self-TI Study (Self-TI) is a pilot study designed to measure acceptability and feasibility of HPV self-testing among transgender and non-binary people in England. (English)
METHODS AND ANALYSIS (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
TMNB people aged 25-65 years, with at least 1 year of testosterone, and TWNB people, aged 18 years and over, are eligible to participate. (English)
METHODS AND ANALYSIS (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Participants self-collect up to four samples: an oral rinse, a first void urine sample, a vaginal swab (if applicable) and an anal swab. (English)
METHODS AND ANALYSIS (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
TMNB participants are asked to have an additional clinician-collected cervical swab taken following their routine Cervical Screening Programme sample. (English)
METHODS AND ANALYSIS (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
TWNB people are asked to take a self-collection kit to perform additional self-collection at home and mail the samples back to the clinic. (English)
METHODS AND ANALYSIS (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Acceptability is assessed by a self-administered online survey and feasibility is measured as the proportion of samples returned in the clinic and from home. (English)
METHODS AND ANALYSIS (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Self-TI received ethical approval from the Research Ethics Committee of Wales 4 and ethical review panel within the Division of Cancer Epidemiology and Genetics at the US National Cancer Institute. (English)
ETHICS AND DISSEMINATION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Self-TI was coproduced by members of the transgender and non-binary community, who served as authors, collaborators and members of the patient and public involvement (PPI) group. (English)
ETHICS AND DISSEMINATION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Results of this study will be shared with the community prior to being published in peer-reviewed journals and the PPI group will help to design the results dissemination strategy. (English)
ETHICS AND DISSEMINATION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
The evidence generated from this pilot study could be used to inform a larger, international study of HPV self-testing in the transgender and non-binary community. (English)
ETHICS AND DISSEMINATION (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
NCT05883111. (English)
TRIAL REGISTRATION NUMBER (English)
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. (English)
2024
Sarah S (English)
Jackson (English)
SS
Stewart (English)
O'Callaghan (English)
S
Elanore (English)
Ward (English)
E
Chloe M (English)
Orkin (English)
CM
Megan A (English)
Clarke (English)
MA
Alison May (English)
Berner (English)
AM
Competing interests: AMB is a trustee of OUTpatients, of which SOC is the CEO. (English)
None of the other authors have any conflicts to declare. (English)