Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals (Q29540)
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- Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals.
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals |
No description defined |
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Statements
Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. (English)
BACKGROUND (English)
© 2024. The Author(s). (English)
2024
This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. (English)
BACKGROUND (English)
© 2024. The Author(s). (English)
2024
We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts. (English)
BACKGROUND (English)
© 2024. The Author(s). (English)
2024
Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT. (English)
METHODS (English)
© 2024. The Author(s). (English)
2024
While alpha and beta diversity remained unchanged during transition, specific species, including Parabacteroides goldsteinii and Escherichia coli, exhibited significant abundance shifts aligned with affirmed gender. (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
Overall functional metagenome analysis showed a statistically significant effect of gender and transition (R<sup>2</sup> = 4.1%, P = 0.0115), emphasizing transitions aligned with affirmed gender, particularly in fatty acid-related metabolism. (English)
RESULTS (English)
© 2024. The Author(s). (English)
2024
This study provides compelling evidence of distinct taxonomic and functional profiles in the gut microbiota between trans men and women. (English)
CONCLUSIONS (English)
© 2024. The Author(s). (English)
2024
GAHT induces androgenization in trans men and feminization in trans women, potentially impacting physiological and health-related outcomes. (English)
CONCLUSIONS (English)
© 2024. The Author(s). (English)
2024
Clinicaltrials.gov NCT02185274. (English)
TRIAL REGISTRATION (English)
© 2024. The Author(s). (English)
2024
Timur (English)
Liwinski (English)
T
Matthias K (English)
Auer (English)
MK
Johanna (English)
Schröder (English)
J
Ina (English)
Pieknik (English)
I
Christian (English)
Casar (English)
C
Dorothee (English)
Schwinge (English)
D
Lara (English)
Henze (English)
L
Günter K (English)
Stalla (English)
GK
Undine E (English)
Lang (English)
UE
Alina (English)
von Klitzing (English)
A
Peer (English)
Briken (English)
P
Thomas (English)
Hildebrandt (English)
T
Jeanne C (English)
Desbuleux (English)
JC
Sarah V (English)
Biedermann (English)
SV
Paul-Martin (English)
Holterhus (English)
PM
Corinna (English)
Bang (English)
C
Christoph (English)
Schramm (English)
C
Johannes (English)
Fuss (English)
J
17 September 2024
2 September 2024