Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study (Q29293): Difference between revisions
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Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study | |||
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Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP) | |||
Latest revision as of 20:35, 6 November 2024
No description defined
- Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study.
- Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP)
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study |
No description defined |
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Statements
The global burden of sexually transmitted infections (STIs) poses a challenge in the context of HIV pre-exposure prophylaxis (PrEP) programmes. (English)
BACKGROUND (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
We aimed to explore factors associated with prevalent, incident, and recurrent STIs in men who have sex with men (MSM) and transgender women on PrEP in Brazil, Mexico, and Peru. (English)
BACKGROUND (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
ImPrEP was a prospective, single-arm, open-label, multicentre study that enrolled MSM and transgender women in the context of the public health systems of Brazil (14 sites), Mexico (four sites), and Peru (ten sites) between February, 2018, and June, 2021. (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Eligibility criteria followed regional PrEP guidelines at the study start, including participants aged 18 years and older, not living with HIV, and reporting at least one of the following in the previous 6 months: condomless anal sex (CAS), anal sex with partner(s) living with HIV, any bacterial STI, or transactional sex. (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Eligible participants were screened and enrolled on the same day to receive daily oral PrEP (tenofovir disoproxil fumarate 300 mg and emtricitabine 200 mg). (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
We assessed three outcomes: prevalent bacterial STIs, incident bacterial STIs, and recurrent bacterial STIs. (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Testing occurred at baseline and quarterly for syphilis, anorectal chlamydia, and anorectal gonorrhoea. (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Behavioural data were collected at baseline and quarterly. (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
The study was registered with the Brazilian Registry of Clinical Trials, U1111-1217-6021. (English)
METHODS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Among all 9509 participants included in the ImPrEP study (3928 [41·3%] in Brazil, 3288 [34·6%] in Mexico, and 2293 [24·1%] in Peru), 8525 (89·7%) had available STI results at baseline and were included in the prevalent STI analysis, and 7558 (79·5%) had available STI results during follow-up and were included in the incident and recurrent STI analyses. (English)
FINDINGS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
2184 (25·6%) of 8525 participants had any bacterial STI at baseline. (English)
FINDINGS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
STI incidence during follow-up was 31·7 cases per 100 person-years (95% CI 30·7-32·7), with the highest rate for anorectal chlamydia (11·6 cases per 100 person-years, 95% CI 11·0-12·2), followed by syphilis (10·5 cases per 100 person-years, 9·9-11·1) and anorectal gonorrhoea (9·7 cases per 100 person-years, 9·2-10·3). (English)
FINDINGS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Although only 2391 (31·6%) of 7558 participants had at least one STI during follow-up, 915 (12·1%) participants had recurrent diagnoses, representing 2328 (61·2%) of 3804 incident STI diagnoses. (English)
FINDINGS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Characteristics associated with prevalent, incident, and recurrent STIs included younger age, multiple sex partners, receptive CAS, substance use, and previous STI diagnoses at baseline (incident or recurrent only). (English)
FINDINGS (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Our findings underscore the nuanced dynamics of STI transmission among MSM and transgender women across Latin America, highlighting an urgent need for tailored interventions to mitigate STI burden effectively, especially among the most susceptible individuals. (English)
INTERPRETATION (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Unitaid, WHO, and ministries of health (Brazil, Mexico, and Peru). (English)
FUNDING (English)
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
For the Portuguese and Spanish translations of the abstract see Supplementary Materials section. (English)
TRANSLATIONS (English)
no value
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. (English)
2024
Mayara Secco (English)
Torres Silva (English)
MS
Thiago Silva (English)
Torres (English)
TS
Carolina (English)
Coutinho (English)
C
Ronaldo (English)
Ismério Moreira (English)
R
Iuri (English)
da Costa Leite (English)
I
Marcelo (English)
Cunha (English)
M
Pedro Henrique Amparo (English)
da Costa Leite (English)
PHA
Carlos F (English)
Cáceres (English)
CF
Hamid (English)
Vega-Ramírez (English)
H
Kelika A (English)
Konda (English)
KA
Juan (English)
Guanira (English)
J
José (English)
Valdez Madruga (English)
J
Sandra (English)
Wagner Cardoso (English)
S
Marcos (English)
Benedetti (English)
M
Maria Cristina (English)
Pimenta (English)
MC
Brenda (English)
Hoagland (English)
B
Beatriz (English)
Grinsztejn (English)
B
Valdilea (English)
Gonçalves Veloso (English)
V
Marcus Vinicius (English)
Lacerda (English)
MV
José Valdez (English)
Madruga (English)
JV
Alessandro (English)
Farias (English)
A
Josué N (English)
Lima (English)
JN
Ronaldo (English)
Zonta (English)
R
Lilian (English)
Lauria (English)
L
J David (English)
Urbaez-Brito (English)
JD
Polyana (English)
d'Albuquerque (English)
P
Claudio (English)
Palombo (English)
C
Paulo Ricardo (English)
Alencastro (English)
PR
Raquel Keiko de Luca (English)
Ito (English)
RKL
Júlio (English)
Moreira (English)
J
João L (English)
Benedetti (English)
JL
Fabio V (English)
Maria (English)
FV
Paula M (English)
Luz (English)
PM
Lucilene (English)
Freitas (English)
L
Kim (English)
Geraldo (English)
K
Monica (English)
Derrico (English)
M
Sandro (English)
Nazer (English)
S
Tania (English)
Kristic (English)
T
Renato (English)
Girade (English)
R
Renato (English)
Lima (English)
R
Antônio R (English)
Carvalho (English)
AR
Carla (English)
Rocha (English)
C
Pedro (English)
Leite (English)
P
Marcio (English)
Lessa (English)
M
Marilia (English)
Santini-Oliveira (English)
M
Daniel R B (English)
Bezerra (English)
DRB
Cleo de Oliveira (English)
Souza (English)
CO
Jacinto (English)
Corrêa (English)
J
Marcelo (English)
Alves (English)
M
Carolina (English)
Souza (English)
C
Camilla (English)
Portugal (English)
C
Mônica Dos Santos (English)
Valões (English)
MDS
Gabriel Lima (English)
Mota (English)
GL
Joyce Alves (English)
Gomes (English)
JA
Cynthia Ferreira Lima (English)
Falcão (English)
CFL
Fernanda Falcão (English)
Riberson (English)
FF
Luciano (English)
Melo (English)
L
Talita Andrade (English)
Oliveira (English)
TA
Agnaldo Moreira (English)
Oliveira Júnior (English)
AM
Bruna (English)
Fonseca (English)
B
Leonor Henriette (English)
Lannoy (English)
LH
Ludymilla Anderson Santiago (English)
Carlos (English)
LAS
João Paulo (English)
Cunha (English)
JP
Sonia Maria de Alencastro (English)
Coracini (English)
SMA
Thiago Oliveira (English)
Rodrigues (English)
TO
Emília Regina Scharf (English)
Mettrau (English)
ERS
Kelly Vieira (English)
Meira (English)
KV
Heder (English)
Tavares (English)
H
Ana Paula Nunes Viveiros (English)
Valeiras (English)
APNV
Taiane Miyake Alves de Carvalho (English)
Rocha (English)
TMAC
Alex (English)
Amorim (English)
A
Patrícia (English)
Sabadini (English)
P
Luiz Gustavo (English)
Córdoba (English)
LG
Caio (English)
Gusmão (English)
C
Erika (English)
Faustino (English)
E
Julia Soares da Silva (English)
Hansen (English)
JSDS
Agatha Mirian (English)
Cunha (English)
AM
Neuza Uchiyama (English)
Nishimura (English)
NU
Jaime Eduardo Flygare Razo Prereira (English)
Santos (English)
JEFRP
Aline Barnabé (English)
Cano (English)
AB
Willyam Magnum Telles (English)
Dias (English)
WMT
Magô (English)
Tonhon (English)
M
Tania Regina (English)
Rezende (English)
TR
Alex (English)
Gomes (English)
A
Eloá Dos Santos (English)
Rodrigues (English)
EDS
Maria das Dores Aires (English)
Carneiro (English)
MDDA
Alexandre (English)
Castilho (English)
A
Mariana (English)
Carvalho (English)
M
Sergio (English)
Bautista-Aredondo (English)
S
Heleen (English)
Vermandere (English)
H
Steven (English)
Diaz (English)
S
Dulce (English)
Diaz-Sosa (English)
D
Centli (English)
Guillen-Diaz-Barriga (English)
C
Rebeca (English)
Robles (English)
R
Maria Elena (English)
Medina-Mora (English)
ME
Marcela (English)
González (English)
M
Ivonne Huerta (English)
Icelo (English)
IH
Araczy Martinez (English)
Davalos (English)
AM
José Gomez (English)
Castro (English)
JG
Luis Obed Ocampo (English)
Valdez (English)
LOO
Fernanda Ramírez (English)
Barajas (English)
FR
Verónica Ruiz (English)
González (English)
VR
Galileo Vargas (English)
Guadarrama (English)
GV
Israel (English)
Macías (English)
I
Jehovani Tena (English)
Sánchez (English)
JT
Juan Pablo Osuna (English)
Noriega (English)
JPO
H Rodrigo (English)
Moheno M (English)
HR
Jorge M Bernal (English)
Ramírez (English)
JMB
Víctor Dante Galicia (English)
Juarez (English)
VDG
Gerardo (English)
Vizcaíno (English)
G
Francisco Javier (English)
Arjona (English)
FJ
Cesar Vidal (English)
Osco Tamayo (English)
CV
Hector Javier (English)
Salvatierra Flores (English)
HJ
Yovanna Margot (English)
Cabrera Santa Cruz (English)
YM
Ricardo Martín (English)
Moreno Aguayo (English)
RM
Gino (English)
Calvo (English)
G
Silver (English)
Vargas (English)
S
Oliver (English)
Elorreaga (English)
O
100
Ximena (English)
Gutierrez (English)
X
101
Fernando (English)
Olivos (English)
F
102
Damaris (English)
Caviedes (English)
D
103
Daniella (English)
Adriazola (English)
D
104
Eduardo (English)
Juárez (English)
E
105
Gabriela (English)
Mariño (English)
G
106
Jazmin (English)
Qquellon (English)
J
107
Francesca (English)
Vasquez (English)
F
108
Jean Pierre (English)
Jiron (English)
JP
109
Sonia (English)
Flores (English)
S
110
Karen (English)
Campos (English)
K
111
3 October 2024
2 October 2024
Declaration of interests We declare no competing interests. (English)